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However, the identification of mechanisms by which this group of SNPs might be associated with IC 50 values remains a challenge

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In COPD, this balance is disruptedprimarily manifested as enhanced protease activity and diminished antiprotease activity ( 1-antitrypsin (AAT) represents the most active antiprotease in the lungs, capable of binding to proteases such as neutrophil elastase (NE) at a 1:1 molar ratio to mitigate tissue damage

The Judicial Panel on Multidistrict Litigation consolidated the case in February, 2024