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Consequently, the present review aims to more comprehensively summarize the current understanding of the involvement of GLP-1RAs across distinct categories of pain, elucidate their mechanisms of action, and shed light on the future direction of clinical investigations by incorporating findings from newly published studies on GLP-1RAs in pain modalities

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The negative control analyses did not find any clinically meaningful differences, providing some reassurance about the analytical approach

Firth SM, Baxter RC

Several studies have reported that GLP-1 and the GLP-1 receptor stimulate the activity of FoxO1 that plays a crucial role in cellular metabolism through SIRT-1-dependent FoxO1 deacetylation and Akt-dependent FoxO1 phosphorylation (Bastien-Dionne et al., 2019)