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It can act as a tumor suppressor 8,9,10,11,12 and an oncogene 13,14,15,16,17 , according to published reports

Main Genetic Factors Predisposing You to Histamine Intolerance Certain genetic variations can predispose you to histamine intolerance, including those in the following genes: MTHFR : MTHFR helps regulate methylation which is needed to reduce intracellular histamine by the HNMT route

Variants in genes such as PNPLA3 , TM6SF2 , MBOAT7 , and GCKR have been linked to altered hepatic lipid metabolism, fibrosis susceptibility, and disease severity

Ramkhelawon B, Yang Y, van Gils JM, Hewing B, Rayner KJ, Parathath S, Guo L, Oldebeken S, Feig JL, Fisher EA, Moore KJ

Peter Vash, M.D., an endocrinologist and obesity medicine specialist based in Los Angeles