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This damage inhibits calcium (Ca 2+ ) influx, disrupting the excitationcontraction coupling of cardiomyocytes and leading to heart failure

Methods Cells, reagents Human PCa cell lines DU145 and 22Rv1 were from Cancer Research UK Laboratories (Clare Hall Hertfordshire UK) and Professor Sir Walter Bodmer (University of Oxford, UK) respectively

The NWLSS Glutathione Assay is a modification of the method first described by Tietze