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A recent study showed that nearly 1 in 6 patients with cirrhosis have moderately severe to severe depression and nearly half have moderatesevere anxiety (43)

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All structural figures were constructed using PyMol 35

These findings suggest that dopaminergic neurons, muscularis macrophages, enteric neurons, and enteric glia share a microenvironment that enables dopaminergic neuroimmune signaling

a , Scheme of the in vitro sgRNA competition assay performed in HEK-293T SLC25A39 knockout cells expressing a vector control or SLC25A39 cDNA transduced with a pool of 5 control sgRNAs (sgControl, gray) and sgRNAs targeting TXNRD2 (pink) and SLC25A40 (green) (left)