Licensed entities have been caught cutting corners Recently, several licensed compounding pharmacies and their ingredient wholesalers were sanctioned for distributing illegal peptides and peptide ingredients not allowed in compounding
10.1021/bi00347a025 76 BrewsterD
Where they overlap and where they don't Complementary Mechanism Targets Target Origin BPC-157 Gastric juice protein fragment (15 amino acids) TB-500 Thymosin Beta-4 fragment (LKKTETQ region) Target Primary action BPC-157 Local tissue repair signaling TB-500 Systemic cell migration and mobilization Target Angiogenesis BPC-157 VEGF upregulation, NO pathway TB-500 Endothelial migration, VEGF crosstalk Target Cell migration BPC-157 Indirect, via growth factors TB-500 Direct (G-actin sequestering) Target Best-evidence tissue BPC-157 Tendon, gut, gastric mucosa (preclinical) TB-500 Cardiac, corneal, skin (preclinical + early human T4) Target Reported in vivo half-life BPC-157 ~4 hours (animal estimates) TB-500 ~23 days (animal estimates) Half-life figures are pharmacokinetic estimates from animal studies
If those fatty acids are not burned through a caloric deficit or exercise, they circulate briefly and are re-stored
Chawla LS, Chen S, Bellomo R, Tidmarsh GF (2018) Angiotensin converting enzyme defects in shock: implications for future therapy
