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Dapagliflozin once-daily and exenatide once-weekly dual therapy: A 24-week randomized, placebo-controlled, phase II study examining effects on body weight and prediabetes in obese adults without diabetes

The three receptor systems it targets are commonly studied because each contributes a distinct part of metabolic regulation: GLP-1 receptor signalling is studied for appetite regulation, glucose dependent insulin secretion, and gastric motility related effects

10.1016/S0140-6736(09)60659-0 142

Because the two medications interact with the brain and gut slightly differently, a patient who struggles with one may find the other much easier to manage

Accessed 03/07/24