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The possible reason for the protective effects being more prominent in cells pretreated with L-NAC was the greater and more sustainable intracellular NAC levels that can be achieved via liposomal delivery (Figure 1(b))

For instance, pairing a peptide that activates glutathione-associated pathways with one that stabilizes mitochondrial membranes can both reduce ROS generation and accelerate repair

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Eur J Clin Nutr 58:391402 Kipp AP, Strohm D, Brigelius-Floh R, Schomburg L, Bechthold A, Leschik-Bonnet E, Heseker H (2015) Revised reference values for selenium intake

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