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SC semaglutide significantly attenuates aortic plaque lesions in nondiabetic low-density-lipoprotein-receptor-deficient mice in a dose-independent manner and affects genes related to atherosclerosis [50]
This is not specific to retatrutide but occurs with any significant caloric deficit
10.1097/00003086-199404000-00046 24 DamienC
Int J Biol Macromol 214:542553 Huang HS, Ma MC, Chen J (2008) Chronic L-arginine administration increases oxidative and nitrosative stress in rat hyperoxaluric kidneys and excessive crystal deposition
In other words, something released by the gut upon eating enhances insulin secretion beyond what rising glucose alone would stimulate
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