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The role of oxidative stress in neurodegenerative diseases

The cystine transporter SLC7A11 critically restores/maintains intracellular GSH

When complete G6PD deficiency was produced in mouse embryonic stem cells by targeted inactivation of the G6PD gene, the G6PD-null cells thus obtained were viable, but they formed colonies only in a low-oxygen environment

Other studies have shown how low glutathione levels may be a risk factor for paracetamol hepatotoxicity in alcoholics because a lower dose of paracetamol will be necessary to deplete GSH below the critical threshold concentration where hepatocellular necrosis starts to occur

Tumor Biol 2014;35(1):493-499