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Mechanistic & Translational Research Studies Beyond large efficacy trials, numerous mechanistic studies have elucidated how cagrilintide produces its effects and how combination with semaglutide generates synergy

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These bacteria contain genes for sulfate reduction to reduce sulfate to H 2 S, damaging the gut barrier 29 and producing endotoxins 30 and pro-inflammatory cytokines such as IL6 31,32