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In a DSS-induced colitis model, piperine administration increased the levels of Lactobacillus and Bifidobacterium , decreased Enterobacteriaceae , and improved colonic histopathology

Research shows that taking 3 g per day for six weeks can saturate keratinocytes in the skin, but taking more does not increase levels and may cause diarrhea

For comparisons between two groups, two-tailed unpaired and paired t tests or MannWhitney U tests were performed

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Because the design involved multiple peptides and did not isolate each contribution, the data do not map cleanly onto a single receptor-pair interaction