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Description

Wegovys active substance, semaglutide, is a GLP-1 receptor antagonist

Weight management outcomes depend on numerous factors beyond medication alone

Both are FDA-approved approaches, but injections are more targeted, longer acting, and generally associated with greater average weight loss

A review published in Diabetes, Obesity and Metabolism described glucagon receptor agonism as a mechanism that directly increases energy expenditure, meaning the body burns more calories at rest (Pocai, 2014)