does semaglutide cause diarrhea Diarrhea? Side Effects Explained Struggling with Ozempic Diarrhea? Here's

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A study in the New England Journal of Medicine found that among adults who were overweight or obese, those who injected semaglutide weekly lost nearly 15% of their body weight after 68 weeks

GLP-1 receptor agonists slow gastric emptying, which may cause stomach contents to remain present longer than expected despite appropriate fasting

Safety really comes down to proper dosing and patient selection by a licensed provider. A 2025 review that assessed the safety profiles of both drugs found that the most common adverse effects are the same for both tirzepatide and semaglutide, namely, nausea, vomiting and diarrhea