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Glossary 3Tg mouse model of Alzheimer disease Mice that harbour the human APP transgene containing the Swedish mutation, a PSEN1 knock-in with the M146V mutation and the MAPT transgene containing the P301L mutation

Supplementary material The Supplementary Material for this article can be found online at: Abbreviations AQ amodiaquine AQ-SG 5-glutathion- S -yl-amodiaquine AQ-QI amodiaquine-quinoneimine BSO L -buthionine-sulfoximine CDNB 1-chloro-2, 4-dinitrobenzene CYP cytochromes P450 DEAQ N -desethylamodiaquine DEAQ-SG 5-glutathion- S -yl- N -desethylamodiaquine DEAQ-QI N -desethylamodiaquine-quinoneimine DMEM Dulbeccos modified Eagle medium DMF N,N -dimethylformamide ER endoplasmic reticulum FBS fetal bovine serum GSH glutathione GSSG glutathione disulfide GST glutathione S -transferase H 2 O 2 hydrogen peroxide HClO 4 perchloric acid HRP horseradish peroxidase NQO1 NAD(P)H:quinone oxidoreductase 1 NAPQI N -acetyl- p -benzoquinonimine PBS phosphate-buffered saline QI quinoneimine

8.4 Emerging diagnostic and monitoring applications Novel applications of antioxidants also extend into diagnostic realms

A leaky gut can lead to food allergies and sensitivities by allowing undigested food particles to enter the bloodstream, where they trigger immune responses