The peptide downregulates TNF- (6.2-fold reduction) and IL-6 (4.1-fold reduction) while upregulating anti-inflammatory IL-10 (8.1-fold increase)[12]
Thus, the increase in H 2 O 2 production for the combinations after 24 hours reflects the enrichment analysis of the proteomics data, which indicate enhanced ROS production and less ROS removal ( Figure 7B )
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Gross necropsy and histopathologic examination of animals receiving high-dose BPC-157 found no organ damage in liver, spleen, lung, kidney, brain, thymus, prostate, ovaries, or gastric wall