Poison induced pica in rats
Published by Cambridge University Press on behalf of The Nutrition Society Methotrexate (MTX, 4-amino-N10-methyl folic acid), an antagonist of folic acid, is commonly used as a chemotherapeutic drug to treat a variety of cancers and inflammatory diseases (Reference Puig1)
Unlike classical peptide GLP-1 agonists (such as semaglutide or liraglutide), which require parenteral administration, small-molecule compounds exhibit oral bioavailability , opening new possibilities for investigating GLP-1 receptor signaling pathways
Transient and mild stress (such as transient ischemic preconditioning) can induce moderate mitophagy to exert a protective effect, while sustained and high-intensity stress (such as long-term severe ischemia and severe oxidative stress) is prone to trigger excessive mitophagy, shifting the regulatory effect toward damage
Neurochemistry International, 89 , 227-233