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Meanwhile, serum levels of SOD, CAT, and glutathione peroxidase are reported to be elevated

Although Cys can be generated via the transsulfuration pathway in some cell types, in many other cell types, at least in vitro , the import of cystine via system is significant for maintaining the levels of Cys and GSH, and preventing ferroptosis (Magtanong and Dixon, 2018)

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argued that ACSL4 guided ferroptotic cell death by remodeling the cellular lipid composition[26]