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While these diseases have distinct etiologies and pathologies, they all involve neuronal loss and sustained activation of the brains immune system, including microglia and astrocytes ( A key driver of neuronal injury is oxidative stress, which arises when the generation of reactive oxygen species (ROS) overwhelms the brains antioxidant defenses, one such defense being glutathione (GSH) ( GSH is the most abundant endogenous antioxidant in the brain and plays an important role in counteracting oxidative stress ( This review focuses specifically on how GSH affects immune cells in the brain, specifically CNS-resident glial cells such as microglia and astrocytes

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Theoretical Basis for Synergy The potential for synergy between NAD+ and AOD9604 stems from their complementary mechanisms: NAD+ for Cellular Foundation: NAD+ optimizes the fundamental machinery of the cell

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