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IGF-1 LR3 has an arginine instead of a glutamic acid at the third position in its amino acid sequence and an additional 13 amino acids at its N-terminus
Interestingly, the elevated CHAC1 levels in TP53-mutant cells might represent an adaptive response, potentially compensating for defective ferroptosis pathways or preventing harmful GSH accumulation
Es wird bevorzugt in der Leber gebildet, kommt aber in allen Zellen des Organismus vor, in besonders hohen Mengen (abgesehen von der Leber) in den roten Blutkrperchen und den Zellen des Immunsystems
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