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For individuals with IBS-C, the constipating effect of reduced motility can become severe enough to warrant treatment discontinuation

Slower-than-expected weight loss on tirzepatide doesn't necessarily indicate treatment failureit may reflect individual differences in GLP-1 and GIP receptor sensitivity, baseline metabolic health, lifestyle factors, and medication timing

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Severe dehydration from gastrointestinal symptoms may lead to acute kidney injury, so adequate hydration is important