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In aged mice, it nearly doubles muscle fiber size and enhances muscle stem cell proliferation, resulting in superior muscle regeneration post-injury 1

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While age and sex cannot be modified, knee OA is strongly associated with lifestyle factors that can be controlled

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The target itself was validated by a 2014 Nature study showing NNMT knockdown in mouse fat and liver protected against diet-induced obesity by augmenting cellular energy expenditure (Kraus 2014, PMID 24717514) [2]

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