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Pathogenic variants of the Spartan ( SPRTN ) gene, which encodes a protein that is essential in the maintenance of genomic stability, have reported to be associated progeroid features, lipodystrophy and hepatocellular carcinoma (156)

In metastatic prostate cancer, docetaxel-based chemotherapy, which stabilizes microtubules, remains a first-line treatment

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The ventral pallidum (VP) receives GABAergic inputs from the nucleus accumbens and projects to the mediodorsal thalamic nucleus and prefrontal cortex, forming the cortex-striatum-cortex loop, which regulates motivated behavior and reward evaluation (23)