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Such effects may be of physiological significance, especially if localized to specific cells in certain conditions, eg, during plant responses to pathogens

10.1016/j.plantsci.2005.05.020 100 MachensF.BeckerM.UmrathF.HehlR

PHH/PMH have some disadvantages including difficulty in culture, phenotype change at an early stage, metabolic enzymes easy inactivation, and individual differences between donors, which limit their practicability and reliability as an in vitro model