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Disease activity markers, including polyarthritis, dactylitis, and systemic inflammation, were linked to higher CV event risk, and atherosclerotic plaque burden correlated with PsA severity

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Livingstone, the missionary explorer famous for his journeys through Africa, survived using quinine to combat malaria.[ref] Quinine can be transferred to breast milk

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Instead of overcoming the metabolic adaptation, higher doses frequently exacerbate side effects like nausea, fatigue, and gastrointestinal distress