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According to research, Breg activity can be inhibited by downregulating the expression of the thioredoxin (TXN) gene, which encourages the development of pro-inflammatory B cells and causes systemic inflammation (85)

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A significantly increased risk of vitamin B 12 deficiency was observed in the AA group vs GG in individuals assigned to metformin (OR 3.85 [95% CI 1.62, 9.15]