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Gallbladder disease : Including cholelithiasis and cholecystitis, particularly in those experiencing substantial weight loss Renal impairment : Secondary to dehydration from gastrointestinal side effects Ileus/intestinal obstruction : Post-marketing reports exist with GLP-1 receptor agonists (causality not established)

Paragon, Fabien Milliat et Claude Lutton, Dietary l-Carnitine Supplementation in Obese Cats Alters Carnitine Metabolism and Decreases Ketosis during Fasting and Induced Hepatic Lipidosis , The Journal of Nutrition , vol

Some people may experience improvements sooner, while others may need longer

By 8-12 weeks at a stable dose, the majority of patients experience minimal or no side effects

GLP-1 provides the appetite suppression foundation, but GIP fundamentally changes how the body responds metabolically in ways that dramatically amplify weight loss beyond what GLP-1 alone achieves