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Furthermore, the trend lower rates of severe hypoglycemia in the GLP-1RA group could have contributed to the better cardiovascular outcomes in those patients, because severe hypoglycemia is strongly associated with, and can precipitate, cardiovascular events [37]

Several chemical compounds are associated with the disruption of the enzymatic antioxidant system ( Figure 2 ) ( Figure 2 ) Between pH 2.0 and 5.6, the phosphate acid is deprotonated, resulting in a negative charge allowing the interaction with monovalent cations

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Januvia - Clinical Pharmacology 12.1 Januvia Mechanism of Action Sitagliptin is a DPP-4 inhibitor, which is believed to exert its actions in patients with type 2 diabetes mellitus by slowing the inactivation of incretin hormones