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6.2 Linking GSH/GSSG to Transcriptomic and Proteomic Regulation Transcriptomic and proteomic data can connect metabolite changes to functional modules: GCLC/GCLM/GSS for synthesis, SLC7A11 for substrate acquisition, GSR/GPX/GST for regeneration and use, pentose phosphate pathway enzymes for NADPH supply, and NRF2-KEAP1 signaling for coordinated antioxidant adaptation

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As an oxidized molecule finds the electrons it seeks to achieve neutrality, it goes from a positive charge to neutral charge, thereby returning to the reduced state

Extended data Extended Data Fig

Translational oncology