moving from tirzepatide to semaglutide Conversion semaglutide: dosing, timing & results (2026) How Does Tirzepatide Work? |

Gradual weight loss typically starts within the first few weeks, but significant weight loss generally occurs over 12 to 16 weeks as your body adjusts

Knees, hips, and ankles adjust to new movement patterns, which may create soreness similar to starting a new exercise routine

One exception is Alli (orlistat) , which contains the same active ingredient as Xenical, but is available over the counter

You might also experience mild changes in your energy levels or digestive patterns as your body begins the work of stabilizing blood sugar and shifting its hormonal balance

GLP-1 receptor agonists work by mimicking the glucagon-like peptide-1 hormone stimulating insulin release, reducing appetite, and slowing gastric emptying