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In addition, several stress- and metabolism-related genes such as oxidative stress-induced growth inhibitor 1 ( OSGIN1 ), solute carrier family 7 member 11 ( SLC7A11 ), haem oxygenase 1 ( HMOX1 ) and glucose-6-phosphate dehydrogenase ( G6PD ) were also induced

Note: The diluent is normal saline (0.9% NaCl) or PBS (0.01 M, pH 7.4)

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To rescue the Al 2 O 3 NPs induced mitochondria dysfunction, disruption of small molecular metabolites of HBE were profiled using metabolomics analysis, which facilitates identification of potential antagonizer or supplement against nanoparticle-involved damages

Intervention and Placebo the intervention group received cysteine-rich whey protein isolate (CRWP), commercially available as Immunocal, which was provided by Immunotec Inc