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Results typically begin at week 4 to 6 and compound through week 12: because MOTS-c works through mitochondrial gene expression and metabolic pathway activation rather than appetite suppression, the timeline is slower than GLP-1 therapies but produces different, complementary changes in metabolic function

Furthermore, another 8.&% were forced to reduce their dose of semaglutide 2.4 mg

However, as this was an observational study, further research is needed to establish causality and understand the underlying mechanisms

It mimics a naturally occurring hormone that helps regulate blood sugar levels and increases feelings of fullness, thus reducing food intake

GLP-1 receptors are expressed throughout the brain, and their activation promotes neuronal survival, reduces neuroinflammation, and improves synaptic plasticity