Together, these mechanisms relax blood vessel walls and lower the force of blood pushing against arterial walls
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Initially, main concerns were receptor-activating activity while recently, downstream effects of GLP-1R and GIPR have been more and more revealed that not only receptor activation promotes cAMP and stimulates insulin releasing, but also other factors (-arrestin recruitment, residence time, etc.) influence receptor internalization, which further elicits long-term effects in vivo
Interesting, but not a replacement for proven therapy
Note: This article is for educational purposes only