It is hypothesized that this synergism arises because PMs increase the permeability of the bacterial OM, allowing greater intracellular penetration of curcumin
In all models, the following fixed covariates were entered: assigned treatment (investigational product or placebo), baseline measurement of the outcome of interest, visit (day 14 1 day or day 28 1 day), visit in interaction with treatment, period (period 1 or period 2), sex and, for MIDT outcomes, incentive level
Dig Dis Sci 67 , 54395443 (2022)
Pain Monitoring: After the injection, youll be monitored briefly to ensure there are no adverse reactions
A tissue distribution study revealed no statistically significant difference in DiR distribution between the control liposomes and COXP liposomes in heart, liver, and spleen while significantly higher distribution was observed in the brain (~9 fold) and kidneys (~9 fold) for DiR delivered by COXP liposomes when compared with that from the control liposomes
