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M., de Melo, A
Biologics like belimumab or anifrolumab have specific immune targets that could overlap with or be affected by peptide mechanisms
Conversely, in a recent randomized, double-blind, placebo-controlled study involving twenty healthy volunteers, a once-weekly injection of a GLP-1R agonist, dulaglutide, for three weeks did not influence HPA axis activity, showing no significant effects on circadian rhythms of blood or salivary cortisol secretion, and the level of this hormone also was not changed after the dexamethasone suppression test in comparison with the placebo-receiving group [78]
Recent studies have identified an important endocrine/paracrine role for the BAT in regulating the function of a variety of organs, including the heart, through BAT-derived molecules, also termed batokines [34]
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