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2 (1993): 169177, 10.1002/syn.890140210
To investigate the importance of sAC in GLP-1(2836)stimulated cAMP generation in human caECs, we also blocked the anion (HCO 3 ) entry required for sAC activity using probenecid (39)
This exceeded outcomes reported for semaglutide (~15%) and tirzepatide (~22%) in comparable timeframes, representing the largest effect size for any metabolic peptide in published Phase II data at that time
This has driven interest in alternative mechanisms and combination approaches that might deliver comparable efficacy with improved side effect profiles
Endothelial nitric oxide synthase in vascular disease: from marvel to menace
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