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509,516 Proteasome inhibition can, in principle, target any of the three proteolytic sites of the proteasome, 1, 2, and 5, and the majority of proteasome inhibitors developed to date target the 5/5i subunits

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528,537,538,539 Bortezomib, carfilzomib, and ixazomib indiscriminately target both the constitutive 26S proteasome and the immunoproteasome