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Highly reactive species such as hydroxyl radical (OH) and perhydroxyl radical (HO 2 ) emerge from secondary interactions involving O 2 - NAFLD progression is further driven by insulin resistance (IR), ER stress, and the activation of the unfolded protein response (UPR) pathway [52, 53]

As estrogen levels decrease, insulin signaling can become less efficient, meaning the pancreas may need to release more insulin to manage the same amount of glucose

Begin with once weekly dosing before increasing to twice weekly