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Mechanistically, SLC25A39 deficiency induced mitochondrial dysfunction, characterized by excessive mitochondrial reactive oxygen species (ROS), reduced membrane potential, diminished adenosine triphosphate (ATP) synthesis, aberrant mitochondrial permeability transition pore (mPTP) opening, and cytochrome c release

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Although pancreatic fat is elevated in both obese non-diabetic and obese-T2D subjects, it is believed to be a feature independently related to T2D (3436)

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Age Requirement: Must be 18 years of age or older