B12 deficiency may rarely cause blue-grey hyperpigmentation or nail thinning, though nail changes are uncommon
[6] [25] At levels only slightly below normal, deficiency can result in fatigue, headaches, feeling faint, rapid breathing, pale skin, numbness or tingling, poor appetite, heartburn, poor balance, difficulty walking, poor reflexes, blurred vision, memory problems, depression, irritability, inattention, cognitive decline, dementia, and even psychosis
It is also effective for neuropathy, delayed wound healing, scurvy, and symptoms like weakness, fatigue, and reduced immunity caused by vitamin deficiencies
Participants receiving higher doses achieved average weight loss of up to 24% over a 48-week period
0.8 kg in placebo over 24 weeks) that did not meet the magnitude needed for regulatory approval