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The chronic pain problem: where the evidence and the biology diverge The most common leap I see is the leap from maybe helpful for an acute tendon injury to maybe helpful for arthritis, chronic knee pain, or long-standing degenerative issues. This is where I think the case is weak

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Ok, so these are interesting points but please add this into the mix for future answers: The NICE Guideline clearly states that there is insufficient research why some people need more frequent injections than others and that an 8- or 12- weekly schedule does not work for everyone and some may need more frequently