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Paudel YN, Angelopoulou E, Piperi C et al (2020) Emerging neuroprotective effect of metformin in Parkinsons disease: a molecular crosstalk

In turn, the gut modulates the central nervous system by producing microbiota-derived metabolites and products, neuroactive substances, peptides, and gut hormones

Approved products for these uses are available domestically, which is precisely why the "no effective treatment available in the U.S." criterion does not apply

Signs of degradation include cloudiness in previously clear solution, visible particles or precipitate, unusual odor, or discoloration