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Abnormal early cleavage events predict early embryo demise: sperm oxidative stress and early abnormal cleavage

van MegenFSkodjeGILergenmullerSZhlkeSAabakkenLVeierdMBet al

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Receptor engagement initiates Gs-mediated adenylyl cyclase activation and intracellular cAMP elevation in somatotroph cell models, triggering pulsatile growth hormone (GH) release

Then, NAPQI-modified proteins were digested via two proteases (trypsin and pepsin) in parallel and analyzed by two-dimensional LC-MS/MS, using high-pH reversed-phase (RP) offline fractionation