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Before opening, unused pens or vials must stay refrigerated (3646F), so an insulated travel case with cooling packs provides security for longer flights

Semaglutide weekly weight loss varies, but most see steady progress with proper adherence

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Combination with Insulin with or without Metformin In a 26-week double blind trial (Trial 6, NCT03021187), 731 adult patients with type 2 diabetes mellitus inadequately controlled on insulin (basal, basal/bolus or premixed) with or without metformin, were randomized to semaglutide tablets 3 mg, 7 mg and 14 mg orally once daily or placebo once daily

Fatigue is common in the early weeks, especially if caloric intake drops significantly