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The great improvement detected in ED degree category should be regarded with caution considering that, in the l-ARG cohort, only 24% of patients, mainly belonging to the baseline category of mild ED, reached IIEF-6 scores compatible with absence of ED, whereas the majority of patients improved the category by remaining within the range of ED

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This interaction has been confirmed clinically: in renal transplant recipients, 0.2 g berberine three times daily for three months increased cyclosporine AUC by 34.5 % and prolonged its half-life by 2.7 h [150,151], while in heart transplant patients, a 25 % increase in cyclosporine blood levels was observed [152]

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