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The heart

GCN2 kinase in T cells mediates proliferative arrest and anergy induction in response to indoleamine 2,3-dioxygenase

Additionally, IL-6, through the JAK-STAT3 pathway, increases the phosphorylation of TRPV1 in dorsal root ganglion (DRG) neurons, 78 inducing visceral pain after gastrointestinal cytokine stimulation

The result is a more tolerable heat that can be sustained for longer sessions, especially useful for people who find traditional sauna heat too intense