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this leads to a malabsorption of the vitamin Certain medications use long term metformin use and chronic acid-reducing drugs decrease the absorption of vitamin B12 from food particles Malignancy of the pancreas or bowel Folic acid deficiency Semaglutide Semaglutide is contraindicated in patients with a history of angioedema, anaphylaxis, or other serious hypersensitivity reaction to semaglutide

Defects in CoQ 10 biosynthesis, or impairments in the redox machinery required to maintain CoQ 10 in its reduced form (CoQ 10 H 2 , ubiquinol), can compromise ETC function

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