Polymeric nanoparticles, especially those derived from PLGA (poly(lactic-co-glycolic acid)), have been used to prepare long-acting formulations of GLP-1 that can extend the release period to weeks with a single dose, reducing injection frequency and improving patient adherence [33]
In terms of weight loss effectiveness , semaglutide GLP-1 does have an edge over liraglutide, according to current research
However, with a proliferation of manufacturers, the dangers of counterfeiting and substandard quality are likely to be multiplied
the glucagon analogue, HM15136 90
In taste buds, GLP-1 is locally produced from proglucagon through the cleavage by prohormone convertase PC1/3, which is co-expressed with GLP-1 in all taste cells positive for this peptide