overeating on semaglutide How to Stop Weight Regain After Taking Semaglutide? Semaglutide: A Breakthrough in Weight

Key Points Glucocorticoids modulate growth hormone (GH) secretion at both the hypothalamic and pituitary level Hypoadrenalism might cause GH deficiency that is reversible during glucocorticoid replacement therapy Testing for GH deficiency in patients with hypopituitarism should always be performed after adequate periods of cortisol replacement Chronic excess of glucocorticoids, either exogenous or endogenous, causes GH deficiency that might be involved in metabolic and cardiovascular complications Treatment with recombinant GH could be considered in children and adults with glucocorticoid-induced GH deficiency This is a preview of subscription content, access via your institution Access options Subscribe to this journal Receive 12 print issues and online access $189.00 per year only $15.75 per issue Buy this article Purchase on SpringerLink Instant access to the full article PDF

In the Novo Nordisk-funded study, published on 22 October 2025, researchers from University College London (UCL) analysed data from the SELECT trial (published in 2023) of 17,604 people from 41 countries aged 45 years and over, who were overweight and had cardiovascular disease (CVD) but did not have diabetes

A group of researchers, including oncologists and data scientists, from the University of Florida and Indiana University hypothesized that GLP-1s hold promise in oncology due to their ability to lower glucose, adiposity, insulin resistance, and systemic inflammation factors associated with cancer progression, according to a July 2025 paper published in JAMA

10.1016/j.ejphar.2019.172835 44 SmithC.Patterson-CrossR.WoodwardO.LewisJ.ChiarugiD.MerkleF.et al (2022)

Wnt/-catenin and NFB signaling synergize to trigger growth factor-free regeneration of adult primary human hepatocytes