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A second candidate, Eli Lilly's orforglipron, is an oral non-peptide small-molecule GLP-1 receptor agonist that posted positive Phase 3 results yet remained unapproved as of April 2026

For everyone else, including the uninsured, Medicare beneficiaries, and those with insurance that excludes weight loss medications, both brand-name cash-pay and compounded alternatives now offer viable paths to treatment

Novo Nordisk has announced results from the phase 3 REDEFINE 4 trial, a head-to-head study comparing CagriSema (a GLP-1 + amylin combination) with tirzepatide for obesity treatment